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Pop-up screening nested within routine community activities unmasks an addressed cardiovascular risk: A pilot study (Gippsland Healthy Heart Study)
CONCLUSIONS: This study supported the feasibility and effectiveness of pop-up screening to detect CVRF in rural communities.PMID:37735862 | DOI:10.1111/ajr.13042
Source: The Australian Journal of Rural Health - September 22, 2023 Category: Rural Health Authors: Masashi Fujino Julie Butters Mark Boyes Noel Duncan Fleur Streets Amy Sabatini Alan Herschtal Adam J Nelson Stephen J Nicholls Source Type: research

Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
CONCLUSIONS: During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.PMID:37738035 | DOI:10.1097/GME.0000000000002245
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Samar R El Khoudary Xirun Chen Ziyuan Wang Maria M Brooks Trevor Orchard Sybil Crawford Imke Janssen Susan A Everson-Rose Daniel McConnell Karen Matthews Source Type: research

Effects of < em > Aeriscardovia aeriphila < /em > on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration of A. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application of A. aeriphila in poultry production.PMID:37735944 | DOI:10.1631/jzus.B2200621
Source: J Zhejiang Univ Sci ... - September 22, 2023 Category: Science Authors: Muhammad Zahid Farooq Xinkai Wang Xianghua Yan Source Type: research

A nomogram based on the preoperative neutrophil-to-lymphocyte ratio to distinguish sarcomatoid renal cell carcinoma from clear cell renal cell carcinoma
ConclusionNLR is a potential indicator for preoperative differentiation of SRCC and CCRCC, and the predictive model constructed based on NLR has a good predictive ability. The new model could provide suggestions for the early identification of SRCC.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated ...
Source: Biology Direct - September 22, 2023 Category: Biology Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Rapha ëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers and Heidi M. McBride Tags: Research Source Type: research

Robustness of Heteroaggregates Involving Hydrophobic Cholesterol and its Mimetics
Phys. Chem. Chem. Phys., 2023, Accepted Manuscript DOI: 10.1039/D3CP02174B, PaperRituparna Hazra, Durba Roy Exploring the self and cross aggregation affinity of cholesterol (CHL) and some of its lookalikes, e.g., cholesteryl hemisuccinate (CHM), campesterol (CAM) and arjunic acid (ARJ) provides crucial understanding towards the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 21, 2023 Category: Chemistry Authors: Rituparna Hazra Source Type: research

Effects of epicatechin on cardiovascular function in middle-aged diet-induced obese rat models of metabolic syndrome
This study aimed to investigate the cardiovascular effects of epicatechin, a flavonoid found in green tea and cocoa, in attenuating complications associated with metabolic syndrome in diet-induced obese rats.Male Wistar-Kyoto (WKY) rats aged 16 weeks were fed either standard rat chow (SC) or given a high-fat-high-carbohydrate (HFHC) diet for 20 weeks. Epicatechin treatment (5mg/kg/day) was administered to a subset of WKY rats commencing at week 8 of the 20 week HFHC feeding period. Body weights, food, water and energy intakes, blood pressure, heart rate and glucose tolerance were measured throughout the treatment period. O...
Source: The British Journal of Nutrition - September 21, 2023 Category: Nutrition Authors: Kylie Connolly Romeo Batacan Douglas Jackson Andrew Fenning Source Type: research

The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research

Single-Cell Hemoprotein Diet Changes Adipose Tissue Distributions and Re-Shapes Gut Microbiota in High-Fat Diet-Induced Obese Mice
This study suggests the potential of heme-SCP as an anti-obesity supplement, which modulates serum biochemistry and gut mi-crobiota in high-fat diet-induced obese mice.PMID:37734921 | DOI:10.4014/jmb.2308.08046
Source: Journal of Microbiology and Biotechnology - September 21, 2023 Category: Biotechnology Authors: Seungki Lee Ahyoung Choi Kyung-Hoon Park Youngjin Cho Hyunjin Yoon Pil Kim Source Type: research

The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research

Soluble receptor for advanced glycation end-products (sRAGE) in childhood obesity: association with gene expression of RAGE and cardiometabolic markers
CONCLUSIONS: expression of RAGE is associated with lower sRAGE levels in childhood obesity. Moreover, obese children show higher cardiometabolic risk markers, and a positively associated with sRAGE.PMID:37732356 | DOI:10.20960/nh.04666
Source: Nutricion Hospitalaria - September 21, 2023 Category: Nutrition Authors: Celia Aradillas-Garc ía Mariela Vega-C árdenas Juan Manuel Vargas-Morales Diana Patricia Portales-P érez Armando G ómez-Ojeda Claudia Luevano-Contreras Source Type: research

The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research

How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future! Digital health should become an organic part of primary care in the future I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs

Molecules, Vol. 28, Pages 6732: Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives
Rekka Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membrane lipid peroxidatio...
Source: Molecules - September 21, 2023 Category: Chemistry Authors: Christina Nouni Panagiotis Theodosis-Nobelos Eleni A. Rekka Tags: Article Source Type: research

Correction: The roles of different microRNAs in the regulation of cholesterol in viral hepatitis
Source: Cell Communication and Signaling - September 21, 2023 Category: Molecular Biology Authors: Xuan Meng, Yeganeh Eslami, Ehsan Derafsh, Anwar Saihood, Nikoo Emtiazi, Saman Yasamineh, Omid Gholizadeh and Renzon Daniel Cosme Pecho Tags: Correction Source Type: research